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Still, clinicians should treat adherence to GLP-1 treatment as an important outcome in its own right not an afterthought, Al-Aly said in the release

We demonstrate that the therapeutic potential of GLP-1RAs in RA is mediated by their dual targeting of two key pathological pathways: suppressing a previously unidentified cGAS-STING-ferroptosis axis in chondrocytes and reprogramming synovial macrophages toward an M2 reparative phenotype, which collectively helps maintain joint homeostasis

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The interaction potential may also extend to herbal supplements that affect glucose metabolism or gastrointestinal function

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