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Join us as they discuss how these medications might influence pain pathways and what it means for the headache and migraine community

Semaglutide inhibits your appetite and the emptying of your stomach, naturally reducing the amount of food you eat and the calories you consume, resulting in weight loss

Persistent or worsening symptoms despite dietary modifications and over-the-counter interventions lasting more than 2-3 weeks should be discussed with your prescribing clinician, as this may indicate inadequate tolerance to the current dose or the need for alternative management strategies

Of note, a recent meta-analysis encompassing those clinical trials focused on the cardiovascular safety of GLP-1 RAs found significant reductions in MACE3 (a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke), hospitalization for heart failure and progression of chronic kidney disease [8]

As a result, GLP- 1's primary effects include decreasing body weight, protecting against cardiovascular disease, and lowering fasting and postprandial blood glucose levelsall of which are therapeutic targets in T2DM
