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RCT: randomized controlled trial

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[23] [26] Current evidence is insufficient to establish efficacy, optimal dosing, or safety profiles in RA populations without diabetes or obesity

The growing prevalence of HFpEF is well recognized

20 Moreover, the high amount of visceral fat and epicardial adipose tissue (EAT), as well as associated plasma volume expansion, in obese individuals results in significant haemodynamic impairment at rest and during exercise, exerting local effects on the heart

Conclusion This comprehensive review highlights the therapeutic potential of GLP-1 and its analogs in the management of metabolic disorders, particularly T2DM