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[DOI] [PMC free article] [PubMed] [Google Scholar] [132].Filippatos TD, Panagiotopoulou TV, Elisaf MS

Common Gastrointestinal Side Effects Gastrointestinal symptoms represent the most frequent adverse events with Retatrutide, consistent with other GLP 1 class medications

Short-term use only (under 12 weeks due to movement disorder risk)

This drug is mostly metabolized by the liver through the cytochrome P450 (CYP) enzyme system, primarily by CYP3A4 and, to a lesser extent, CYP2C8

Mice with PVN-selective deletion of GLP-1R (using Sim1 cre) have impaired stress-induced HPA axis activation, and this is further accompanied by protection from stress-induced weight loss, reduced stress-induced cardiovascular endpoints and reduced anxiety-like behavior [813]

The expected timing, dose-matching logic, and washout considerations are covered in switching from tirzepatide to retatrutide