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Lancet, 368, 16961705

62 The connection between GLP-1RAs and gallbladder disease Clinical observations have increasingly indicated a possible link between GLP-1RAs use and an elevated risk of gallbladder disease

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Increased energy expenditure One of the most important theoretical advantages of glucagon receptor activation is increased energy expenditure

Tanday et al., (2022) have since described a role for Y1-R agonism in inducing periods of -cell rest that, when combined with GLP-1R agonism, proved beneficial in obesity-driven models of diabetes

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