are the glp 1 drugs safe Scientists cautiously suggest GLP-1s to use around pregnancy GLP-1 Medications for Weight Loss:

GLP-1s can also cause gastrointestinal issues such as nausea and vomiting, which may cause some people to discontinue use due to side effects before achieving their weight-loss goals

Clinical Efficacy: Evidence from Major Trials Weight Loss Outcomes in Non-Diabetic Patients The clinical efficacy of GLP-1 agonists for weight loss in non-diabetic patients has been demonstrated across multiple large-scale randomized controlled trials

Additionally, its important to discuss any concerns you have about potential side effects with your doctor or other healthcare professional to make sure the medication is right for you

In overweight humans, liraglutide 3 mg solidly inhibits gastric emptying after 5wk of treatment, but the efficacy markedly decreases after 16wk of treatment, yet with still significant effect relative to placebo treated controls [808]

Furthermore, exendin-4 can stimulate the cyclic adenosine monophosphate/protein kinase A (cAMP-PKA) pathway by activating GLP-1R, which then increases the level of non-phosphorylated -catenin to stimulate the Wnt/-catenin/NeuroD1 pathway and inhibits the activity of GSK-3, ultimately decreasing the hyperphosphorylation of AD-associated tau proteins regulated by GSK-3 (Reich and Hlscher, 2022)

Furthermore, when treated with an AOM, patients with obesity have experienced weight regain upon cessation of the AOM [10, 54]