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The mechanisms underlying these CV benefits include promoting myocardial glucose uptake and utilization, reducing oxidative stress, inhibiting cardiomyocyte apoptosis, vasodilation, improving coronary blood flow, natriuresis, anti-inflammatory effects, renal protection, reducing plaque formation, and neurohormonal regulation (22)

Effect of Oral Semaglutide on Cardiovascular Parameters and Their Mechanisms in Patients with Type 2 Diabetes: Rationale and Design of the Semaglutide Anti-Atherosclerotic Mechanisms of Action Study (SAMAS) Diabetes Ther

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have been extraordinarily successful at pushing insulin production up and driving too-high blood sugar levels down

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