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Enrolled patients were previously treated with gemcitabine-based therapy but were nave to HER2-targeted therapy

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Common side effects observed in clinical trials include: Nausea Vomiting Diarrhea Stomach pain Constipation Weight loss Less common but serious side effects may include: Severe allergic reactions Thyroid tumors, including medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN 2) Pancreatitis Diabetic retinopathy complications Hypoglycemia, especially with other diabetes medications Worsening kidney disease Gallbladder disease and gallstones This is not a full list

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Their signaling pathways and biological effects are different

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