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This molecule targets the activin receptor signaling pathway, a validated therapeutic target for pulmonary hypertension

Epidemiology of nonalcoholic fatty liver

Onoharigho RA, Crook M, Jalil M, Godschall EN, Dame EG, Dawer A, Belmont-Rausch DM, Pers TH, Lutas A, Habib N, Gler AD, Krashes MJ, Campbell JN (2024) Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety

Cardiovascular effects: Retatrutide's glucagon receptor agonism may influence heart rate and blood pressure

Nat Metab 2024;6:290303

However, such in-housing of third-party capacity is worrying the wider industry and could lead to further shortages going forward