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Glucagon-like peptide-1 (GLP-1) is an incretin known for its anti-obesity effects, and several effective drugs targeting GLP-1 receptors (GLP-1Rs) have recently been developed to treat obesity

Understanding the biological and genetic reasons behind treatment resistance is essential for finding the right personalized therapy

Unlike typical mitochondrial proteins, MOTS-c translation occurs exclusively in the cytoplasm rather than within mitochondria

There is no clinically available or recommended blood test to measure GLP-1 receptor agonist medication levels in routine practice

Having demonstrated short-term weight loss with liraglutide in this group of obese adults, we now evaluate safety/tolerability (primary outcome) and long-term efficacy for sustaining weight loss (secondary outcome) over 2 years