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Lee et al., 2021)

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These disparities persisted among overweight and obese subgroups: Asian (HR 0.78, 95% CI 0.680.88), Black (HR 0.78, 95% CI 0.740.81), and Other patients (HR 0.83, 95% CI 0.720.95)

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Upon GLP-1 receptor activation, adenylyl cyclase is activated and cAMP generated, leading, in turn, to cAMP-dependent activation of second messenger pathways, such as the PKA and Epac pathways