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Off-Target Binding: Transporters, Serotonin Receptors, and Clinical Consequences SSRIs are relatively selective for SERT but show low-affinity interactions with other monoamine transporters (norepinephrine transporter (NET) and dopamine transporter (DAT)) and multiple serotonin receptor subtypes

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This complexity means that anyone with existing AFib considering semaglutide injection or other GLP-1 therapy needs individualized assessment rather than a blanket yes or no answer