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Supplementary Information The online version contains supplementary material available at 10.1186/s13098-024-01528-0

If you have specific health conditions such as kidney disease, discuss appropriate protein intake with your healthcare provider or dietitian

Abdominal pain or discomfort affects roughly 20-25% of people, typically mild and temporary

The titration was gentle barely any nausea past week 2 and the care team checks in proactively without me chasing them. Sarah K

In researchers with normal or low-normal blood pressure, the additive blood pressure lowering effect of combining both compounds may produce orthostatic hypotension or lightheadedness, particularly when standing quickly

Due to albumin binding, there is a continuous reservoir of semaglutide in plasma, which leads to persistent exposure of GLP-1 receptors in pancreas as well as in extra-pancreatic targets (hypothalamus, liver, salivary glands)