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In the first placebo-controlled trial, the addition of alogliptin 25 mg qd to MET resulted in statistically significant improvements from baseline in A1C (placebo-subtracted change -0.5)
Sterne JA, Hernn MA, Reeves BC, Savovi J, Berkman ND, Viswanathan M, et al

Whether the low endogenous concentration and the restricted pharmacokinetic action profile of endogenous GLP-1 metabolites are sufficient to elicit such effects under physiological circumstances remains questionable
