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Purpose of Review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.Recent Findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss

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Eli Lilly announced positive topline results from the ATTAIN-2 Phase 3 trial of orforglipron, an oral GLP-1 receptor agonist for obesity and type 2 diabetes.