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Across Eli Lillys SURPASS and SURMOUNT trials, tirzepatide produced larger reductions in both body weight and HbA1c than semaglutide managed in its own STEP program

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However, "stronger" also means stronger side effects, with discontinuation rates of 12-18% for retatrutide versus 5-7% for semaglutide

Injuries such as sciatic nerve damage, shoulder injury related to vaccine administration (SIRVA), and localized tissue necrosis are often preventableyet they continue to occur due to poor technique, inadequate training, or improper site selection

doi: 10.1007/s40618-015-0404-6 29 HabibZAHavstadSLWellsKDivineGPladevallMWilliamsLK
