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As a matter of fact, exendin-4 (50 g/kg/day) treatment increased the expression of SIRT1 and its downstream factor, AMPK, in exendin-4 treated mouse livers and hepatocytes
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As hype around GLP-1 drugs rose, she expected consumers to be looking for alternatives and natural routes to boosting their GLP-1, he said
Yet a poll shows interest in these drugs drops from 45% to 14% if people learn weight returns after stopping therapy

Gobbi et al., 2003
