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The SEMALEAN study, published in 2025, tracked 115 semaglutide patients over 12 months using DEXA scans and found that while total lean mass initially declined, it stabilized by month 12 while fat mass continued dropping throughout

most cases start or exacerbate around hormonal shifts, although some patients note no exacerbation with estrogen-progestin use

The FDA has raised specific concerns about compounded semaglutide products, including reports of adverse events tied to dosing errors and concerns about the use of salt forms not present in FDA-approved formulations

Most founders are still building in-house what they could orchestrate externally in a week because building feels like progress, while routing feels like admitting you dont have a team

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