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Peripheral administration of LIRA leads to its localisation in circumventricular organs and the hypothalamic arcuate nucleus, where it promotes the activation of anorexigenic pathways and the inhibition of orexigenic ones

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This highlights the importance of tumor-specific research, as the drugs benefits in one context may pose risks in another

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[1] The most commonly reported adverse effects of semaglutide are gastrointestinal in nature, reflecting its mechanism of action on the digestive system

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Nasopharyngitis, influenza, cystitis, and viral infection are also commonly reported with these drugs [48, 104-106, 110]

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