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doi: 10.1002/oby.23596, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 38

Despite their benefits, GLP-1 medications present unique challenges at a national level

This has the effect of lowering intraglomerular pressures and reducing single nephron GFR and subsequent proteinuria
middle-aged/older) GLP-1 cycling - which leads to weight-cycling (linked to muscle and bone loss) - 1/3 to 1/2 of US adults go on/off/on etc
In other words, while FDA approval means a drug has met certain standards, it doesn't mean the medication is necessarily covered under your health plan or the best or most cost-effective option for your specific needs
