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Specific deletion of LepR in endothelial cells of the BBB impairs the transport of leptin into cerebrospinal fluid (CSF) and LepR-positive brain regions, leading to aggravated obesity [205]
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More recently, the FLOW study, which focused on evaluating the nephroprotective and cardioprotective efficacy of semaglutide, a GLP-1RA, in patients with T2DM and CKD (N = 3534), was stopped prematurely as it met certain pre-specified efficacy criteria, with a very high likelihood of study success on reducing the progression of renal disease [61]
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