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If interventions are not started, the increased demand for insulin can overload pancreatic -cells leading to pancreatic -cell failure, decreased insulin secretion, and uncontrolled glycemia (Figure 1)

doi: 10.1016/j.mce.2016.11.024

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On the basis of several putative modes of action under investigation (for example, neuroprotective and anti-inflammatory properties, regulation of reward pathways), there is an emerging consensus that GLP-1RAs could be repurposed for use in neuropsychiatric conditions 25,26,27,28,29,30,31,32
