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Curre Res Diabetes & Obes J 2023

16 The most frequent adverse effects of GLP-1 agonists are mild or moderate gastrointestinal issuesmost commonly, nausea and diarrhea

Other animal studies have found that GLP-1R agonists reduce amphetamine use and amphetamine-induced hyperlocomotion

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Lin L., Xu X., Yu Y., Ye H., He X., Chen S., Chen X., Shao Z., Chen P

Of note, exendin-4 was serendipitously discovered in the saliva of the Gila monster ( Heloderma suspectum ) and was revealed to be a GLP-1 analog that is resistant to DPP-4 action in 1992, even before the mechanism of GLP-1 degradation was identified [7]

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