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Introduction Autism spectrum disorder (ASD), or autism, is a lifetime neurodevelopmental disorder characterized by differences in communication and social interaction, along with restrictive and repetitive motor behaviors and atypical sensory experiences(Guze, 1995

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Collaborators GBDCRD

Treatment with Azaserine also redistributed CD36 (red arrows) and Rab-5 (purple arrows) to the plasma membrane (Figure 3D)

Aging has been associated to a more oxidized state in the redox balance (Jones and Sies, 2015), and the central nervous system becomes vulnerable to oxidative stress (Arivazhagan et al., 2005

By inhibiting NNMT, 5-Amino-1MQ reduces the production of 1-methylnicotinamide (MNA), a metabolite that would otherwise deplete cellular nicotinamide pools