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As soon as Mojsov and Deanna Deery, Weir's technician, injected the peptide into the perfused rat, they were astonished to see it secrete insulin, even when given in a tiny dose, the same concentration as the one that circulates in the blood

This metabolic yo-yo effect leaves patients struggling to find stable weight management solutions long after their thyroid disease is 'treated.' Understanding this pattern helps explain why GLP-1 therapy must be individually tailored for thyroid patients

But the biological plausibility is sound, and some clinicians are incorporating this strategy into their long-term GLP-1 treatment plans

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31 , 32 Conversely, the inflammatory process, impaired lung function and/or the use of glucocorticoids in COPD patients may increase the risk of developing diabetes