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The Journal of Clinical Psychiatry, 65 (7), 959965

In some cases, a drug is used off-label for a time and then is approved for that purpose, making it on-label. An example is a drug called topiramate, he adds

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Understanding these distinctions helps consumers evaluate options and have informed conversations with healthcare providers
The process is complicated by the nature of pharmaceutical patent law, which involves not just patents on the drug itself but also on formulations, delivery methods, and manufacturing processes