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While the benefits of full-dose GLP-1 drugs are backed by large clinical trials, microdosing exists almost entirely outside that evidence base

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Off-label use for low-BMI cosmetic weight loss is not supported by the evidence, exposes the patient to real risks (including rapid muscle loss and rebound after discontinuation), and typically isn't covered by insurance

Now, here's the clinically important implication, right

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If constipation becomes a problem despite preparation, options worth discussing with your clinician include: A gentle osmotic laxative such as polyethylene glycol (MiraLAX) used on a scheduled rather than as-needed basis during dose escalation periods