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Healthcare professionals should set realistic expectations, emphasising that neither medication represents a standalone solution and that sustainable weight management requires comprehensive lifestyle modification alongside any pharmacological intervention

Introduction The advent of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their combinations, as pharmacological treatments for obesity and type 2 diabetes, has sparked intense debate about their role relative to traditional lifestyle interventions such as exercise and dietary modification

The rationale for this discrepancy remains to be established, but may lay in differences in baseline drinking or in time of alcohol exposure prior to treatment

Mechanistic candidates supported by recent preclinical and clinical studies include enhanced hippocampal neurogenesis, upregulation of neurotrophic signaling pathways (e.g., brain-derived neurotrophic factor (BDNF)), synaptic remodeling, and neural circuit changes that alter emotional bias processing

The medication activates GLP-1 receptors in your gut and brain, creating a powerful cascade of metabolic changes that lead to measurable weight reduction

[5] Both medications can cause side effects such as nausea, vomiting, and gastrointestinal issues