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The scale may move slowly, but measurements continue improving as body recomposes

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Safety Comparison# Key Differences Summary# Weight loss : Comparable (~20-21%), no head-to-head trial Mechanism : Amylin/GLP-1 (CagriSema) vs GIP/GLP-1 (tirzepatide) Molecules : Two-peptide combination vs single dual-agonist molecule Approval : Tirzepatide is FDA-approved

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11 Proglucagon (160aa residues) is then produced in these tissues by the removal of the signal peptide from the preproglucagon protein

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Trial participants with diabetes achieved 19.7% weight loss plus 2.02% A1C reduction on average

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