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This makes biological sense

This long-term perspective changes the supplementation calculation

When people discontinue these medications, they tend to regain the weight they lost

However, based on six exenatide and five liraglutide placebo-controlled studies ( P =0.055 and P =0.31, respectively), significance was not reached for individual GLP-1RA with an OR of 0.45 (95% CI 0.20, 1.02) for exenatide and 0.60 (95% CI 0.22, 1.62) for liraglutide

According to our results, individuals treated with GLP-1RA were the least persistent at 2 years among the four groups examined, including comparisons to both oral agent and insulin users, which is in agreement with previous studies [17,18,19]

What cardiovascular benefits do GLP-1 medications offer beyond weight loss