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Interestingly, FGF21, SREBP-1c, and FAS mRNA in the liver tissues of the model group of mice and protein expression was increased compared with the control group, while liver kinase B1 (LKB1) mRNA expression was reduced

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However, through the $10 billion acquisition of clinical-stage biotech company Metsera in November 2025, Pfizer secured a next-generation obesity pipeline after an aggressive bidding war with Novo