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CVS Caremark negotiated a deal with Novo Nordisk (Wegovy's manufacturer) that made Wegovy the preferred GLP-1 medication starting July 2025

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However, studies conducted concurrently showed unexpected superiority of once-weekly forms of GLP-1 drug candidates to daily forms, and raised questions as to whether the addition of GIP was necessary for a useful incretin agonist

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Clinical trials have demonstrated that GLP-1 receptor agonists can decrease liver fat content, as measured by magnetic resonance imaging or liver biopsy, and may improve markers of liver inflammation

Microdoses may reduce the effectiveness of the medication