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By mimicking LH, it keeps the testes active even when the pituitary has reduced its natural LH output

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In clinical trials, participants without diabetes on the 15 mg dose for nearly a year lost up to 22.9% of their body weight

For procedures involving iodinated contrast media, FDA labeling recommends stopping metformin at or before the procedure in patients with an eGFR of 30-60 mL/min/1.73m, hepatic impairment, alcoholism, heart failure, or those receiving intra-arterial contrast