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This is one reason some clinicians prefer transdermal over oral estradiol for certain patient profiles

Alpha- and Beta-Cell Abnormalities in Haemoglobin A1c-Defined Prediabetes and Type 2 Diabetes

162,163 Retatrutide (LY-3437943), a novel triple agonist developed by Eli Lilly that targets GLP-1R, GIPR and GCGR, has shown potential in preliminary clinical data for providing excellent blood sugar control and significant weight reduction

doi:10.1016/S0140-6736(23)01302-8 Wharton S, Blevins T, Engberg S, et al

Colhoun HM, Lingvay I, Brown PM, Deanfield J, Brown-Frandsen K, Kahn SE, et al

For some patients, that daily schedule can actually be helpful