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The data on GLP-1 withdrawal suggests roughly 60% of lost weight returns within one year of discontinuing primarily as fat, on a body now carrying less lean muscle than before
S., & Neff, L

Ketamine improves anhedonic phenotypes across species: Translational evidence from the Probabilistic Reward Task

And for people over 60, about one-third have had resting muscle cramps in the past 2 months

Kieffer, T

These medications rely on prolonged use to maintain results, leaving many individuals grappling with dependency, side effects, or diminishing effectiveness over time
