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A seminal July 2022 study in The New England Journal of Medicine found that those taking a lower dose of tirzepatide achieved an average weight reduction of 16%, or 35.5 pounds (16 kilograms), in about a year

But if strength keeps declining, soreness persists beyond 72 hours, or you feel exhausted before sessions begin, your training volume exceeds your current recovery capacity and needs to be reduced

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The glucagon receptor activation (paradoxically) adds metabolic benefits when paired with GLP-1 and GIP , such as promoting energy expenditure and fat oxidation, possibly combating the decrease in basal metabolic rate that accompanies weight loss, and helping reduce liver fat

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Youll notice that the two drugs that launched in 2012 barely scraped $100mm after 4 years of launch, and even GSKs OTC offering didnt surpass $400mm/yr