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doi: 10.1016/j.psyneuen.2019.02.006

Diabetes Obes Metab 2021

Some people with underlying motility issues tolerate semaglutide better than tirzepatide, making the switch potentially beneficial

Practical Considerations Several practical factors affect GLP-1 medication use

Several factors contributed to this concern: Animal studies in rodents showed pancreatic changes, including increased pancreatic mass and cellular proliferation, when exposed to high doses of GLP-1 analogues over extended periods

2.4.2 Neuroendocrinereproductive axis: coupling of appetitive centers and reproductive neurons The expression of receptors in hypothalamic reproductive nuclei provides a biological basis for a direct influence on the reproductive axis