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Conclusion GLP-1RAs show significant promise as a potential disease-modifying therapy for neurodegenerative and inflammatory eye diseases, acting through both systemic metabolic improvements and direct ocular mechanisms, representing a paradigm shift beyond their metabolic indications.

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By exploring human studies and mechanistic insights, this review underscores irisins potential to address global health challenges, such as obesity and type 2 diabetes, while advancing strategies for personalized exercise interventions.

Creatine is the most evidence-backed supplement for supporting lean muscle during caloric restriction (Kreider 2017, ISSN)