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As GLP-1 therapies expand beyond diabetes and obesity, understanding their anti-inflammatory mechanisms may unlock new therapeutic uses

The explanation for the discrepancy in the reduction of MACE in patients treated with SGLT2i in DECLARE-TIMI 58 suggests that the benefits of SGLT2i may be more pronounced in patients with a higher risk of cardiovascular disease

Neuropathic Visceral Pain and Irritable Bowel Syndrome Intrathecal administration of GLP-1 RAs, such as GLP-1 and exenatide, has reduced pain sensitivity in animals

The Physiologist Magazine: American Physiological Society

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The latter finding matches the results obtained in Phox2b-Cre GLP-1 receptor KO mice, lacking GLP-1 receptors in the autonomic nervous system, which have normal body mass and composition in response to both chow and HFD [688], yet exhibit partial attenuation of the anorectic and weight loss effects of peripherally administered GLP-1R agonists [520]