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In the longer term, these drugs significantly reduce the risks of developing distressing and expensive complications such as Type 2 diabetes, heart attacks and kidney failure but their cost provides an immediate financial challenge at a time when NHS budgets are tight.

The most frequently reported adverse effects are gastrointestinal in nature , particularly during the initial weeks of treatment as the body adjusts to the medication

Seek emergency care immediately for chest pain, severe shortness of breath, or neurological symptoms

At microdose levels, the differences may be less pronounced because neither medication is fully activating its target receptors

Hartman ML et al (2020) Effects of novel dual GIP and GLP-1 receptor agonist tirzepatide on biomarkers of nonalcoholic steatohepatitis in patients with type 2 diabetes

Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis