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Shah, R., Reyes-Gordillo, K., Cheng, Y., Varatharajalu, R., Ibrahim, J., & Lakshman, M

Even small issues can signal bigger problems.

Network meta-analysis showed no evidence of differences among all possible comparisons for secondary outcomes (MCV, homocysteine levels, platelet counts, and WBC counts)

106,109,116,117 The implication of this is that cells and tissues possess an extraordinary overcapacity to chelate metal ions

Significance: A gradual increase in headloss is normal as the filter operates, but sudden spikes may indicate an issue, such as air binding or media fouling
