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Nav1.8 is known for its unique property of activating at more negative potentials compared to other voltage-gated sodium channels, which may underlie a hyperexcitable state in EECs (Akopian et al., 1996

Editor-in-Chief, Carlat Report Prescriptions for benzos and z-drugs raised the risk of alcohol and drug use disorders 2-3 fold in a new large, 14-year study

Commun Med (Lond)

The sensory and emotional appeal of rich foods loses its power when someone's brain is getting clear "I'm full" signals

Semaglutide 2.4 mg produces a mean placebo-subtracted weight loss of approximately 1214% over 68 weeks in the STEP trials

While not commonly reported with Pendulum specifically, people sensitive to gut-brain interactions may notice temporary mood fluctuations during the adjustment period