greg yang x reply glp-1 linkin park may 2025 Gpr75 Deletion in Adipocytes Protects From Diet‐Induced Obesity: Changes in Glucose Homeostasis and Inflammatory Responses - Hossain - 2026 - The FASEB Journal PDF) Bipolar and schizophrenia risk
Description
This broadened inclusion criteria allowed for a more comprehensive understanding of drug effects in high-risk groups and supported the expansion of GLP-1R agonist indications beyond glycemic control to include cardiovascular and renal benefits

Kalinderi K, et al
GLP-1R mRNA is expressed in pancreatic islets

Mood and metabolism: anhedonia as a clinical target in type 2 diabetes

Conclusion The evidence is clear: neither GLP-1 medications nor lifestyle changes alone can fully address the challenge of sustainable weight loss
GLP-1 agonists offer a therapeutic option for addressing both hyperglycaemia and weight management in this population
