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Approval in BTC was granted based on results of the Phase III KEYNOTE-966 trial, where Keytruda elicited a significant overall survival benefit in this patient population versus chemotherapy alone, according to Mercks announcement

In addition, data indicate that DPP-4 inhibitors also impact immune cell recruitment and reduced macrophage infiltration seemed to be mediated directly via GLP-1-dependent signaling in a rat nephritis model (71)

Low folate status is a risk factor for development of neural tube defects in the developing foetus

lucidum polysaccharides markedly promoted the abundance of SCFAs-producing bacteria, elevated butyrate and iso-butyrate levels and suppressed the abundance of sulfate-reducing bacteria [188]
