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Large clinical trials running for several years show that GLP-1s not only improve sugar and weight but also reduce heart and kidney risks in many people with type 2 diabetes, with an acceptable safety profile when monitored

On the other hand, understanding the mechanisms through which GLP-1 RAs exert their beneficial effects on CVD provides a theoretical framework for their potential effects on erectile function

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Data Availability Statement This is a review article and does not include any original data

Proper storage and preparation are critical for medication safety and effectiveness

Synovial tissue and GLP-1R signalling Specialized cells, fibroblast-like synoviocytes and macrophage-like synoviocytes reside in the synovial membrane, composed of intimal and subintimal layers, which are responsible for notably producing hyaluronic acid and removing metabolites and matrix degradation debris, respectively [49]