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By David Prince, MD | Montefiore Medical Center Although new GLP-1 agonist weight loss drugs such as Ozempic, Wegovy, Trulicity, and Byetta are currently dominating the headlines, the majority of overweight Americans may not qualify for these medications due to limited availability and insurance plan restrictions

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Conclusions Hypomorphic PAM T2D-risk alleles reduce amidating enzyme activity, elevate circulating GLP-1 levels, and impair GLP-1 post-receptor signaling, culminating in a selective and clinically meaningful reduction in GLP-1RA efficacy

Generic drug entries are now likely to speed up market adoption and cause prices to fall 40-50% by FY27

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