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There were no unexpected safety findings at the Phase 2 stage that would fundamentally alter the risk-benefit profile expected for this class

A signed consent was obtained from all included participants by the QBB, and WGS data used in the current study were obtained from the QGP as previously described 77

11 14 In all trials, the patients who met the inclusion criteria and were assigned to the treatment with either dose of SEM underwent a dose escalation period

However, these reports are relatively uncommon

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60.0, PRR 0.71