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But after clinical trails showed its promising effects on weight loss, in 2021, the FDA approved semaglutide (Wegovy), a once-weekly injection, for weight loss in adults when used in combination with a healthy diet and routine exercise

In obesity, adipocytes and immune cells residing in adipose tissue secrete many proinflammatory factors including tumor necrosis factor (TNF) and interleukin 6 (IL-6), which impact adipose tissue function and produce systemic effects via activation of stress kinases to promote insulin resistance [50,51]

Vijiaratnam N, Girges C, Auld G, Chau M, Maclagan K, King A, Skene S, Chowdhury K, Hibbert S, Morris H, Limousin P, Athauda D, Carroll CB, Hu MT, Silverdale M, Duncan GW, Chaudhuri R, Lo C, Del Din S, Yarnall AJ, Rochester L, Gibson R, Dickson J, Hunter R, Libri V, Foltynie T

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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Therapeutic potential of a novel glucagon-like peptide-1 receptor agonist, NLY01, in experimental autoimmune encephalomyelitis

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