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Our analysis identified a calcium signaling bottleneck as the central explanation for the EVOKE biomarker-clinical disconnect why semaglutide reduced CSF tau and neuroinflammation markers by ~10% yet failed to slow cognitive decline on CDR-SB

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You can read the full paper in Nature here: #Genetics #PrecisionMedicine #GLP1 #Obesity #Biotech #Semaglutide #Tirzepatide #Nature #23andMe #GWAS #ClinicalResearch | 24 comments on LinkedIn