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Notably, Zepbound delivers promising weight loss results from its dual-action tirzepatide formula

The framing around that number was apocalyptic

Gastric bypass increases energy expenditure in rats

An extension analysis of patients from Novo Nordisks own STEP1 trial found that one year after withdrawal of onceweekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained twothirds of their prior weight loss, with similar changes in cardiometabolic variables. If weight rebound is common after cessation of Wegovy and other GLP-1s, payers who cover these drugs may well need to plan for an enormous per-member expenditure for patients who stay on GLP-1s indefinitely

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials